Synthetic Routes to N-9 Alkylated 8-Oxoguanines; Weak Inhibitors of the Human DNA Glycosylase OGG1
The human 8-oxoguanine DNA glycosylase OGG1 is involved in base excision repair WOMENS BASIC TANKS (BER), one of several DNA repair mechanisms that may counteract the effects of chemo- and radiation therapy for the treatment of cancer.We envisage that potent inhibitors of OGG1 may be found among the 9-alkyl-8-oxoguanines.Thus we explored synthetic